Abscess Makes the Heart Grow Fonder

Researchers: Jordin Zuelke, MD; Elizabeth McCarthy, MD; Mark Vanzo, DO; Tyler Raymond, DO

Research focus: Hepatic abscesses are categorized as either amebic or, more commonly, pyogenic. Usually seen in the 5th to 8th decade of life, most pyogenic abscesses are caused by E. Coli, Klebsiella pneumoniae, Streptococci sp., anaerobes, and Enterococci sp. Hypervirulent strains of Klebsiella are a leading cause of pyogenic liver abscesses, these strains produce siderophores and biofilms, rendering them resistant to phagocytosis and neutrophil or complement-mediated killing. Management includes drainage and broad-spectrum antibiotics for four weeks.